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Table 1 HIV + D outcome measures and specific outcomes

From: Effectiveness and cost-effectiveness of integrating the management of depression into routine HIV Care in Uganda (the HIV + D trial): A protocol for a cluster-randomised trial

Outcome Source of data Endpoint
Collected at 3 months Collected at 12 months
Primary outcome
Mean DD symptom severity scores PHQ-9 [41]  
Secondary outcomes    
Mean DD symptom severity scores PHQ-9 [41]  
Remission (proportion with PHQ-9 scores < 5) PHQ-9 [41]
Mean generalised anxiety disorder (GAD) severity scores GAD-7 [47]
Quality adjusted life years (QALYs) EQ-5D-5 L [48]
Days out of work (over 3 months) Patient cost questionnaire
Functional impairment and welfare OxCAP-MH [49]
Patients’ satisfaction with depression care Modified Patient Satisfaction Survey by Ede et al. [50]  
Carers’ perceptions and satisfaction levels with integration efforts at HIV clinic Modified Staff Survey by Ede et al. [50]  
Proportion with virological failure (a proxy measure of adherence; defined as a viral load of 400 copies/ml or more) HIV viral load (copies/ml)  
Reported adherence to ART (proportion of participants who have missed at least one dose of ART in the past three days compared against the baseline value) Assessed by means of the question, ‘Have you missed taking ART in the last 3 days?’ Possible responses 1 = Yes, 2 = No
  1. Key: Carer = lay health worker, case manager, mental health workers; ART  antiretroviral therapy