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Table 2 WHO three essential antipsychotics and other drugs on the 'Essential' list (by drug class) to which they have been compared within randomized trials

From: Using the needs of WHO to prioritise Cochrane reviews: The case of antipsychotic drugs

 

RCTs

Total number of people

Cochrane review

Reference

Up to date?

Chlorpromazine

   vs anticonvulsant agents

2

118

  

   vs antidepressants

12

732

[22, 23]

   vs antihypertensive agents

8

286

  

   vs antiparkinsonian agents

3

80

  

   vs antituberculosis agents

1

25

  

   vs barbiturates

3

750

  

   vs benzodiazepines

9

457

[24, 25]

   vs mood stabilizers

2

49

[2628]

   vs opioid agonist

1

340

  

   vs opioid antagonist

1

60

  

Fluphenazine decanoate

   vs antihypertensive agents

1

17

  

   vs antituberculosis agents

1

55

  

Haloperidol

   vs antiarrhythmic agents

2

30

  

   vs antidepressants

10

774

[22, 23]

   vs antidopaminergic agents

4

146

  

   vs antigout agents

1

46

  

   vs antihypertensive agents

3

122

  

   vs antineoplastic agents

3

101

  

   vs antiparkinsonian agents

8

265

  

   vs antiprogesterone agents

1

80

[29]

   vs benzodiazepines

35

4012

[24, 25]

   vs ethanol

1

35

  

   vs glucose

1

unclear

  

   vs mood stabilizers

23

1648

[2628]

   vs stimulant agents

1

20

  
  1. RCTs: Randomized Controlled Trials
  2. Vs: Versus
  3. : Systematic Reviews or update already exist
  4. ✗: Systematic Reviews or update do not exist